Sinusitis leads to pressure build up in your facial area near nose where sinuses are present and painkillers are useful in relieving the pressure and pain associated. Your sinus doctor would recommend over-the-counter (OTC) painkillers such as ibuprofen. Though they don’t help clearing the infection or the reason behind the sinusitis itself, they help by making the symptoms more tolerable before the sinus medication starts showing results. You can also try some home remedies for sinusitis for similar results.